Multilayer Nanoencapsulation

                   ----------  New Approach for Immune Protection of Human Pancreatic Islets

Home Introduction Principle Design Results Future Work References


There are two directions of optimization of current technology:

1. The first zone should be tuned to optimize the environment of the coated islets in terms to guarantee a long-term viability and functionality. The middle zone should determine the permeability of the capsule as well as offer binding sites for cytotoxic cytokines in order to prevent graft failure. The outermost zone in direct contact to the environmental tissue should moderate the connection to the blood circuit in order of revascularization and reduced fibrosis.


2. Another pressing question that must be answered is can a nanometer thick shell withstand shear forces during an injection process during transplantation and the forces they are exposed to at the transplantation site. Future experiments will be focusing on this issue.







BME 240

Designed by Shan Yang