Magnetic iron oxide nanoparticles
for MR contrast agents

Introduction

Why magnetic nanoparticles?
- Superparamagnetism

How SPIO works as MRI contrast agents?

Commercialized SPIO MRI contrast agents

In vivo detection of biological targets

References

Commercialized SPIO MRI contrast agents

SPIO MRI contrast agents usually consist of iron oxide core coated with dextran, siloxanes, or polyethyleneglycol, and produce very high T2 relaxivities. Metal-doped iron oxide nanoparticles (MEIO, MFe2O4, M=Mn, Fe, Co, Ni) with high mass magnetization are also used to further enhance the relaxation process of the proton nuclear spins. Several commercialized SPIO contrast agents are introduced below. [9]

created by Yoon Kyung Kim

Clinical Medicine: BME240