Implantable Prosthetic Heart Valves

Introduction        Clinical Background        Design Considerations        Mechanical Valves        Tissue-based Valves        Future Developments        References


The heart is responsible for the transport of blood throughout the body.  Blood in the circulatory system flows unidirectionally, thus blood also flows in only one direction through the chambers of the heart.  Heart valves separate these chambers and prevent backflow.  There are four valves (see figure 1) that separate and regulate flow between the chambers of the heart.  These valves are:

Each valve has a set of leaflets (the mitral valve has two, the others have three) which open and close with the flow of blood.  The leaflets themselves are passive, relying only on the flow to open and close them.  Each valve is attached at the base of the leaflets to a papillary muscle, which provides support and limits movement of the valve.

These valves work continuously through one’s lifetime.  Given the load and environment, it is not inconceivable that these valves can malfunction or fail.  Here, we will discuss heart valve replacement designs and their advantages and disadvantages, as well as potential future improvements.  

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