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Future Point-of-Care Diagnostics
Cancer applications
As with most diseases, the early diagnosis and
treatment of cancer is crucial for patient survival and reduced patient
morbidity from advanced stages. In order to detect the signs of cancer earlier
on, we need to develop more sensitive cancer diagnosis methods to detect
primary markers. This would allow us to treat the patient with less severe
treatment options and tailor the therapies to the patients specific needs.
Elisa and other diagnostics tests currently being used to detect disease state
markers are simply not sensitive enough to detect protein markers in their
early stage concentrations. As a result, most protein detection levels that are
detectable already correspond to advanced stages of the disease. Smaller,
faster, more sensitive, and cheaper devices are would be a welcome solution to
replacing the less sensitive, time-consuming, and highly expensive
laboratory-analyses methods. This would lead to new medical practices such as
personal care, and providing important decision making results available at a
patients bedside within a matter of minutes. Such a process would greatly
improve the monitoring of cancer progress and patient therapy.
Although recent advances in molecular biology has led
to amazing improvements in its understanding multiple biomarkers that could be
potential signs for cancer diagnosis, this technology needs to be put into
practice. Point-of-care medical diagnostics devices are the vehicle the medical
industry needs to provide array based biosensors to detect multiple target
proteins in a timely and sensitive manner. The sensitivity of the detection
technology could be used to detect very slight variations from normal conditions
such as DNA mutations in a variety of genes, protein expression, hematocrit and
analyte levels and many other variables. By creating new and innovative
biosensor strategies, we could perform cancer testing and other disease states
more rapidly, inexpensively, and reliably in a decentralized setting. Only the
future will determine whether POCT analysis, presently limited to vital
parameters, will replace the central laboratory in whole or in part.
Future developments to help advance
patient care
Advancing care to not only monitor a patients
analytes, chemical balances, blood count, etc. but to also connect them
directly with their primary care provider and emergency personnel if required,
the patient can receive the necessary medical attention they need right away.
Taking advantage of the wireless, computing, and monitoring technology we have
available, we develop a fully integrated system to provide continuous personal
care for those in need.
Source:
http://depts.washington.edu/bioe/research/d2h2/d2h2.html
Home General Diagnostics Information
Clinical Laboratory Diagnostics
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