Deep Brain Stimlation for Treatment of Severe Mental Disorders
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Origin and History of DBS

 

After being approved in July of 1997 by the FDA in the United States for use in patients with essential temors, the number of Deep Brian Stimulators has grown steadily. Currently, there are over 3,000 DBSs being implanted annually, mainly for essential tremors, Parkinson's Disiese, and dystonia. With advances in imaging, robotics, power sources, and mechanism understanding, DBS is venturing into the field of Mental Disorders. Untreatable cases of major mental depression and obcessive-compulsive disorder are now under investigation for treatment with DBS. There is a greater level of insight that must be granted toward these cases due to the lack of instantaneous feedback that is present in movement disorder.

 

Components of DBS

 

 

 

 

Implantable stimulators consist of three pieces that are all contained inside the body. The main body that controls the pulsing and the power is called the Neurostimulator. It is the pacemaker of the device and generates the electrical impulses that are sent to the brain through the leads.

 

 

 

The leads that run from the neurostimulator to the electrodes consists of four to eight insulated wires. These wires are housed in polyurethane to provide insulation from the surrounding tissue.

 

 

A single probes contains all four of the electrodes. The elctrodes are manufactured out of a platinum/iridium blend. This contact pad is the location of the current output.

Procedure for implantation

 

  • Several optical images of the brain are taken using Computerized Tomography and Magnetic Resonance Imagaing to determine location in brain of the stimulation point, a set of nuclei about the size of a corn kernal.
  • After the target point(s) is selected, an apparatus shown to the right is placed o the patient, a portion of the scalp and skull removed, and the electrodes are either maunally inserted or done with computer assistance.
  • Only local anesthetics are used because of the brains lack of ability to produce pain signals. The patient must also be awake to test brain function in a recording mode with the electrodes.
  • Once the electrodes and leads are in place, a serpate procedure is performed to implant the neurostimulator under the clavicle.
  • Several weeks later the patient returns to program the implanted device.

 

 

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