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What is H.Pylori? Current Diagnostics Point of Care Diagnosis References
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HELICOBACTER PYLORI

Helicobacter pylori is a spiral shaped bacterium (about 3 micrometres long with a diameter of about 0.5 micrometres) that lives in the stomach and duodenum. It has a unique way of adapting in the harsh environment of the stomach. The inside of the stomach is comprised of gastric juices whose main components are digestive enzymes and concentrated Hydrochloric acid. The main purpose of gastric juice is to breakdown the food and to kill the micro-organisms, if any. Hence, before the detection of H.Pylori it was thought that stomach is actually sterile. The figure to the right shows the Electron micrograph of H. pylori.



HOW H.PYLORI PROTECTS ITSELF

H.Pylori takes advantage of the thick layer of mucus present in the stomach for its own protection from gastric juices.H.Pylori uses an enzyme called urease to fight the stomach acid that reaches it. The basic mechanism is conversion of urea to bicarbonates & ammonia which are strong bases. This cloud of bases protects H.Pylori from the acid in the stomach. One more way of protection is that the white cells & other infection fighting agents cannot reach the infection because they cannot easily get through the stomach lining. Now, the white cells are supplied with extra nutrients to fight H.Pylori which in turn feeds on these nutrients and within few days symptoms of gastritis and possibly gastric ulcer are seen. The figure to the left is the pictorial representation of how H.Pylori bacterium protects itself inside the stomach.






MODES OF TRANSMISSION

The exact route of transmission is still under research however it is strongly believed that H.Pylori is transmitted via the oral-oral or fecal-oral route. Gastro-esophalgal reflux is also a known cause of transmittance of this bacterium. In the United States, 30% of the adult population is infected. (50% of infected persons are infected by the age of 60.) The infection is more common in crowded living conditions with poor sanitation. In countries with poor sanitation, 90% of the adult population can be infected. Shown below is a slideshow of the endoscopic images of H.Pylori induced gastritis.


Endoscopy Slide Show:
Helicobacter Pylori-Gastritis:


Start the slide show now!



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