Silk-Based Polymers for Regeneration
BME 240: Introduction to
biomaterial platforms for tissue regeneration are commonly used for a
range of abdominal wall defect repair procedures, including
reconstruction surgeries, bladder slings and hernia repair. A company
called Serica has created a silk-based scaffold for tissue regeneration
to help re-grow anterior cruciate ligament (ACL) tissue in the knee.
The SeriACL™ scaffold is a biocompatible and biodegradable ligament
graft which aims to be a substitute for an autograft or allograft
Data from a randomized controlled
study suggest that Serica's silk-based scaffold resulted in a
significantly higher rate of tissue ingrowth when compared to currently
available synthetic, non-resorbable surgical mesh products. The
silk-based scaffold biodegraded at an ideal rate that supported
load-bearing responsibility of growing host tissue.
Shown to the left is a photographic image of Serica's SeriACL scaffold in place. Below is an example of the scaffold itself.