Home

Background

Microresevoir Theory

Fabrication (1,2)

Microreservoir actuation

Integrated Microchip device

Advantages

References

References

[1] Santini, J.T. et.al. Microchips as Controlled Drug Delivery Devices. Angew. Chem. Int. Ed. 2000, 39, 2396-2047.

[2] Physicians Desk reference (Ed.: R. Arky), Medical Economics Company, Montvale, NJ, USA. 1998, pp. 2587-2589.

[3] Physicians Desk reference (Ed.: R. Arky), Medical Economics Company, Montvale, NJ, USA. 1998, pp. 3139-3150.

[4] D.R. Mathews et.al. Diabetologia 1983, 24, 231-237.

[5] www.mchips.com

[6] Santini, J.T., Cima, M.J., Langer, R. A controlled-release microchip. Nature, Vol 397, 28 Jan 1999. pg. 335-338. 

[7] Wu, B.M. in Microstructural Control During Three Dimensional Printing of Polymeric Medical Devices Thesis, 25±40 MIT (1997).

[8] Langer, R. et.al. Application of Micro- and Nano- Electromechanical Devices to Drug Delivery. Pharmaceutical Research 2006. 1-17. DOI: 10.1007/s11095-006-9906-4.

[9] Maloney, JM. et.al. Electrothermally activated microchips for implantable drug delivery and biosensing. Journal of Controlled Release 109 (2005) 244-255.

[10] Santini, J.T. et al. Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device. Nature Biotechnology. (2006) 24:4. pg 437-438.