Antibody-Based Strategies for
Spinal Cord Remyelination

References

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Background

LINGO-1

Immunoglobulin-M

References

  1. About Spinal Cord Injury. Published online by National Spinal Cord Injury Association, February 21, 2008.
  2. Spinal Cord Injury: Hope through Research.  Published online by National Institute of Neurological Disorders and Stroke (NINDS), updated May 7, 2008.
  3. Figure taken from Institute of Medicine (2001), Multiple Sclerosis: Current Status and Strategies for the Future, page 242.
  4. Bunge MB, Bunge RP, and Ris H (1961).  Ultrastructural Study of Remyelination in an Experimental Lesion in an Adult Cat Spinal Cord.  J. Biophys Biochem Cytol 10(1): 67-94
  5. Mi S, Li X, Shao Z, et al. (2004).  Lingo-1 is a component of the Nogo-66 receptor/p75 signaling complex.  Nature Neuroscience 7: 221-228.
  6. Mi S, Miller RH, Li X, et al. (2005).  LINGO-1 negatively regulates myelination by oligodendrocytes.  Nature Neuroscience 8: 745-7513
  7. Citation and Figure from Mi S, Hu B, Hahm K, et al. (2007).  LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis.  Nature Medicine 13 (10): 1228-1233
  8. Rodriguez M, Miller DJ, Pease LR (applied 2001, granted 2003).  United States Patent 20030185827.
  9. Citation and Figure from Asakura K, Miller DJ, Pease LR, and Rodriguez M (1998).  Targeting of IgMk Antibodies to Oligodendrocytes Promotes CNS Remyelination.  J. Neuroscience 18(19): 7700-7708
  10. Citation and Figure from Warrington AE, Bieber AJ, Ciric B, Pease LR, Van Keulen V, and Rodriguez M (2007).  A recombinant human IgM promotes myelin repair after a single, very low dose.  J. Neuroscience Research 85(5): 967-976

Additional Websites of Interest:
NINDS
The Myelin Project

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