Targeted Cancer Treament Delivery
through the Vasculature

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ENCAPSULATION

Protein

Liposome

 

 

TARGETED DELIVERY

Antibody

Folic Acid

 

 

CONCLUSION

 

 

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References

 

Dixit, V., Van den Bossche, J., Sherman, D.M., Thompson, D.H. & Andres, R.P.

Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au

nanoparticles for selective targeting of folate receptor-positive tumor cells.

Bioconjug Chem 17, 603-609 (2006).

<Pubmed>

 

Gao, X., Cui, Y., Levenson, R.M., Chung, L.W. & Nie, S. In vivo cancer targeting and

imaging with semiconductor quantum dots. Nat Biotechnol 22, 969-976 (2004).

<Pubmed>

 

Goldenberg, D.M. Targeted therapy of cancer with radiolabeled antibodies. J Nucl Med

43, 693-713 (2002).

<Pubmed>

 

Quintana, A. et al. Design and function of a dendrimer-based therapeutic nanodevice

targeted to tumor cells through the folate receptor. Pharm Res 19, 1310-1316 (2002).

<Pubmed>

 

Wang, S. & Low, P.S. Folate-mediated targeting of antineoplastic drugs, imaging agents,

and nucleic acids to cancer cells. J Control Release 53, 39-48 (1998).

<Pubmed>

 

 

Review Article on various targeting techniques

 

Dubowchik, G.M. & Walker, M.A. Receptor-mediated and enzyme-dependent targeting

of cytotoxic anticancer drugs. Pharmacol Ther 83, 67-123 (1999).

<Pubmed>

 

 

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