The DNA Microarray:

        Approaching Personalized Medicine

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Leukemia Research    Studying AML    Studying B-CLL

 

Clinical outcome of b-cell type chronic lymphocytic leukemia varies from patient to patient.  Some experience a rapid progression of the cancer with a fatal outcome, while others develop a more stable disease with normal life expectancies.  The ability to recognize the different forms of this disease quickly is important for those who need the most aggressive treatment.  While a valid prognosis can be made, this is labor intensive process require a team of professionals of varied clinical specialties.

In 2005, Schoers et al. studied a group of 252 patients with B-CLL.  Patients were grouped into three categories based on their expression (or non-expression) of ZAP-70 and CD38 proteins, which they showed were related to a positive or negative prognosis. Their gene expression profile was then characterized using an Affymetrix produced oligonucleotide microarray which probed for approximately 5600 genes and compared it against a subset of 35 patients whose gene expression profile was already known from another published study.  Through supervised analysis, they were able to identify 37 genes that exhibited a distinct profile between the three categories.   This study supports the assertion made by Schwaenen et. el in a 2004 paper that  automated array-based genetic profiling could be performed in a clinical setting.

 

 

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